OBJECTIVE

To evaluate the antibiotic resistance and vancomycin resistance in Enterococcus isolated from infections at Nguyen Tri Phuong Hospital from 2019 to 2022.

METHODS 

Enterococcus strains isolated from various infections at Nguyen Tri Phuong Hospital from 2019 to 2022. Bacterial strains were identified by routine microbiological laboratory methods. Antibiotics performed by disk diffusion and determined vancomycin MIC by E-test. The antibiotic results were interpreted according to CLSI standards.

RESULTS

418 Enterococcus strains were isolated, in which E. faecalis (60.52%) and E. faecium (39.48%). Bacterial strains are derived from infection of urinary tract (45.54%), respiratory tract (25.3%), pus – exudate (21.2%), blood (7.95%). Enterococcus was resistant to erythromycin (81.13%), tetracycline (74.13%), ciprofloxacin (54.40%), levofloxacin (51.12%), penicillin (35.27%), ampicillin (32.59%). There is a difference in antibiotic resistance between E. faecium and E. faecalis, and between vancomycin-resistant and vancomycin-non-resistant Enterococcus strains. In this study, E. faecalis were not resistant to vancomycin, meanwhile vancomycin-resistanct E. faecium were 10.36% with 128µg / mL in MIC90.

CONCLUSION

Enterococcus is resistant to many antibiotics, including vancomycin, so the infection control strategy and the use of antibiotics to limit the increase in antibiotic resistance is needed.

Keywords: vancomycin, Enterococcus, E. faecalis, E. faecium.

Graph 1: The   proportion   (%)   of   Enterococcus according to specimens

Graph 2: Distribution of MIC values of vancomycin on Enterococcus

Picture 1: One of the antibiotic sensitivity testing of Enterococci with Vancomycin sensible